What Meds

Psychiatric Medications

Brand Name: Wellbutrin, Budeprion XL, Budeprion SR, Buproban, Wellbutrin SR, Wellbutrin XL, Zyban

Wellbutrin is the brand name for Bupropion, a type of antidepressant (aminoketone class) that also acts as a stimulant. It is a norepinephrine and dopamine reuptake inhibitor. It blocks transporters for chemicals norepinephrine and dopamine, increasing amounts of both chemicals in the brain.

Wellbutrin's effects can usually be felt in one to four weeks.

Why is this drug prescribed?
Wellbutrin is FDA-labeled in adults for depression associated with seasonal changes, major depressive disorder, and smoking cessation assistance.

Wellbutrin is also used to treat:

Bupropion is also used to help people stop smoking. When it is prescribed for this reason, it is marketed under the brand name Zyban, which contains a different dosage of Bupropion than drugs used to treat mental disorders, and is prescribed differently.

How much of this drug is typically used?
Tablet: 75 mg, 100 mg
Tablet, sustained release: 100 mg, 150mg, 200mg
Tablet, extended release: 150 mg, 300 mg 

Warnings and Precautions
The safety and effects of Wellbutrin in children under 18 years old are not known.

Wellbutrin causes significant weight loss (more than 5 pounds) in 28% of people who take it. It should be not be used when such weight loss might be dangerous to the patient.

Wellbutrin may impair coordination or mental abilities: patients should not drive or operate heavy machinery until it is known that Wellbutrin does not affect the ability to safely engage in such activities.

For Pregnant or Nursing Mothers: Wellbutrin's effects during pregnancy are not well understood; Wellbutrin is not recommended for pregnant women. Wellbutrin does pass into breast milk and could cause a serious reaction in the infant; women should not breast-feed while taking this medication.

Bupropion should Not be used for people with the following medical conditions:

Wellbutrin may be used with caution in people with the following conditions:

Adverse Reactions
Bupropion may cause the following reactions:


Interactions with Drugs and Other Substances
Drugs or substances that may interact with Bupropion include:

Use in Child Psychiatry
Safety and efficacy have not been established in children or adolescents. Not recommended to patients with history of seizures, anorexia, or bulimia as can increase risk of seizures. Bupropion is cited in old reviews of benefit in ADHD children and adolescents. Thus, it is often used third-line to treat ADHD, and particularly in children with depression and ADHD.  It has a different mechanism of action than the SSRIs.  As with other antidepressants, it should be used with caution in people with bipolar disorder. The medication carries a special warning, as with other antidepressants, of increased suicidal thinking and behavior in children, adolescents and young adults.


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