What Meds

Psychiatric Medications


Quetiapine
Brand Name: Seroquel

Overview
Seroquel is the brand name for Quetiapine. Seroquel is an atypical antipsychotic agent, a type of drug used to reduce hallucinations, delusions, and psychomotor excitation in patients with schizophrenia and other psychoses. This drug blocks multiple receptors, including dopamine, serotonin, histamine, and alpha, in the brain.

Certain side effects of Seroquel like akathisia and tremor are less severe than in standard antipsychotic medications. Seroquel treats both positive and negative symptoms of schizophrenia.

Seroquel’s effects can usually be felt within 1 to 2 hours.

Why is this drug prescribed?
Seroquel is FDA-approved in adults for the treatment of:

How much of this drug is typically used?
Tablet: 25 mg, 50 mg, 100 mg, 200 mg, 300 mg, 400 mg
XR tablet: 200 mg, 300 mg, 400 mg

Warnings
Studies on Seroquel have only been conducted on adults and the effects of Seroquel on children under 18 years old are not known.

Seroquel may affect a patients ability to drive or operate heavy machinery, especially at the beginning of therapy. Patients should not engage in such activites until the effects of this medication are known.

There is an increased risk of dehydration and heatstroke while taking Seroquel. Patients should drink plenty of fluids and avoid excessive heat.

For Pregnant or Nursing Mothers: Studies in animals indicate that high doses of Seroquel may cause low birth weight and other problems in the fetus. Seroquel is passed into breast milk in animals and breastfeeding is not recommended while taking Seroquel.

Contraindications
Seroquel should Not be used for people with an allergy or hypersensitivity to Seroquel or any of its ingrediants.

Precautions
Seroquel may be used with caution in people with the following conditions:

Adverse Reactions
Seroquel may cause the following reactions:

Seroquel may cause the following reactions:

    • Sedation
    • Low blood pressure on arising
    • Increased cholesterol
    • Weight gain
    • Abdominal pain
    • Constipation
    • Indigestion
    • Dry mouth
    • Increased liver enzymes
    • Dizziness
    • Nasal congestion

Rarely:

    • Fainting
    • Low blood cell counts
    • Neuroleptic malignant syndrome
    • Tardive dyskinesia
    • Suicidal thoughts
    • Prolonged erection

Interactions with Drugs and Other Substances
Drugs or substances that may interact with Seroquel include:

Research Studies and Use in Child Psychiatry
Quetiapine is widely used to treat bipolar mania and depression in adults.  A recent unpublished study found quetipine also effective in treating children and adolescents with bipolar mania.  It is unclear if it is also effective for bipolar depression in children.  Due to sedating properties at lower doses (under 100 mg), it is often used at night to help with sleep.  It has been used commonly in child and adolescent populations for the treatment of bipolar disorder, pervasive developmental disorders, and disruptive behavior disorders.  Expert consensus recommends treatment of acute mania and mixed states in children and adolescents with a mood stabilizer or an atypical antipsychotic such as quetiapine. 

Sources

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