What Meds

Psychiatric Medications


Trifluoperazine
Brand Name: Stelazine

Overview
Stelazine is the brand name for Trifluoperazine, a high potency anti-psychotic medication in a class of drugs called phenothiazines. Anti-psychotic medications are also known as neuroleptics or major tranquilizers. Stelazine is classified as an antianxiety, antiemetic, and antipsychotic drug. This drug blocks receptors for the chemical dopamine in the brain. It also decreases the release of hormones from the hypothalamus and the pituitary gland.

Why is this drug prescribed?
Stelazine is FDA-approved for the treatment of schizophrenia in adults and in children ages 6-12. It is also approved for the treatment of non-psychotic anxiety in adults.

Stelazine is used to treat:

How much of this drug is typically used?
Tablet: 1 mg, 2 mg, 5 mg, 10 mg

Warnings
Children under 12 years old should only take Stelazine under the care of a child psychiatrist.

Stelazine may be given to children as young as 6 years old, but should be done only with extreme caution and careful supervision. In children 6 to 12 years old, starting dose is usually about 1 mg per day. Dosage in children under 12 rarely exceeds 15 mg per day. Stelazine is not habit forming, but if it is taken for a long time it may lead to a serious condition called tardive dyskinesia.

Suddenly discontinuing Stelazine may cause severe withdrawal symptoms such as nausea and vomiting, dizziness, or tremors. Dosage should be gradually tapered over a period of 2 to 3 weeks to minimize withdrawal.

When Stelazine is taken long-term, a riboflavin (vitamin B2) supplement should be taken.

Stelazine may impair coordination or mental alertness. Patients should not drive or operate heavy machinery until they know that Stelazine does not affect their ability to safely engage in such activities.

Stelazine can make it difficult to diagnose certain other medical conditions such as intestinal obstruction, brain tumor, and Reye's syndrome.

For Pregnant or Nursing Mothers: One study in pregnant women did not show an increase in birth defects from taking Stelazine. However, Stelazine is not recommended for pregnant women. Stelazine is excreted in breast-milk and is not recommended for nursing mothers.

Contraindications
Stelazine should Not be used for people with the following medical conditions:

Precautions
Stelazine may be used with caution in people with the following conditions:

Adverse Reactions
Stelazine may cause the following reactions:

Rarely:

Interactions with Drugs and Other Substances
Drugs or substances that may interact with Stelazine include:

Use in Child Psychiatry
This medication is cited in old reviews of management of behavioral problems in pervasive developmental disorders. The older, typical antipsychotics are rarely used in children currently (see haloperidol).

Sources

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